Hsiang-Tsui Wang's reserch lab

發表刊物

Publications (the past five years)

  1. Li S-Y, Tsai M-T, Kuo Y-M, Yang H-M, Tong Z-J, Cheng H-W, Lin C-C*, Wang H-T*. Aldehyde dehydrogenase 2 preserves kidney function by countering acrolein-induced metabolic and mitochondrial dysfunction. JCI Insight. 2024 Oct 8;9(19):e179871. doi: 10.1172/jci.insight.179871 (*Co-corresponding author)..
  2. Teng HW, Wang TY, Lin CC, Tong ZJ, Cheng HW, Wang HT*. Interferon gamma induces higher neutrophil extracellular traps leading to tumor-killing activity in microsatellite stable colorectal cancer. Mol Cancer Ther. 2024 Feb 13. doi: 10.1158/1535-7163.MCT-23-0744 (*Corresponding author).
  3. Jhuo JY, Tong ZJ, PH Ku, Cheng HW, Wang HT*. Acrolein induces mitochondrial dysfunction and insulin resistance in muscle and adipose tissues in vitro and in vivo. Environ Pollut. 2023 Nov 1;336:122380. doi: 10.1016/j.envpol.2023.122380. (*Corresponding author).
  4. Wu TH, Su GY, Liu TY, Wang H-T*, Hwu CM. Urinary acrolein protein conjugates-to-creatinine ratio is positively associated with diabetic peripheral neuropathy in patients with type 2 diabetes mellitus. Endocr Connect. 2023 Oct 5;12(11):e230253. doi: 10.1530/EC-23-0253. (*Corresponding author).
  5. Tsai HC, Tong ZJ, Hwang TL, Wei KC, Chen PY, Huang CY, Chen KT, Lin YJ, Cheng HW, Wang HT*. Acrolein produced by glioma cells under hypoxia inhibits neutrophil AKT activity and suppresses anti-tumoral activities. Free Radic Biol Med. 2023 Oct;207:17-28. doi: 10.1016/j.freeradbiomed.2023.06.027. (*Corresponding author).
  6. Tsou HH, Wang PH, Ting TH, Ping YH, Liu TY, Cheng HW, Wang HT*. Effect of heated tobacco products and traditional cigarettes on pulmonary toxicity and SARS-CoV-2-induced lung injury. Toxicology.2022 Sep;479:153318. doi: 10.1016/j.tox.2022.153318. Epub 2022 Sep 9. (*Corresponding author).
  7. Tong ZJ, Kuo CW, Yen PC, Lin CC, Tsai MT, Lu SH, Chang YP, Liu WS, Tsou HH, Cheng HW, Wang HT*. Acrolein plays a culprit role in the pathogenesis of diabetic nephropathy in vitro and in vivo. Eur J Endocrinol. 2022 Sep 22;187(4):579-592. doi: 10.1530/EJE-22-0493. (*Corresponding author).
  8. Hong JH, Tong ZJ, Wei TN, Lu YC, Huang CY, Huang CY, Chiang CH, Jaw FS, Cheng HW, Wang HT*. Cigarette smoke containing acrolein contributes to cisplatin resistance in human bladder cancers through the regulation of HER2 pathway or FGFR3 pathway. Mol Cancer Ther. 2022 Mar 21, doi: 10.1158/1535-7163.MCT-21-0725. (*Corresponding author).
  9. Wang HT, Lee HW, Weng MW, Liu Y, Huang WC, Lepor H, Wu XR, Tang MS. The role of TAp63γ and P53 point mutations in regulating DNA repair, mutational susceptibility and invasion of bladder cancer cells. Elife. 2021 Nov 8;10:e71184. doi: 10.7554/eLife.71184.
  10. Tsai HC, Wei KC, Chen PY, Huang CY, Chen KT, Lin YJ, Cheng HW, Chen YR, Wang HT*.Valproic Acid Enhanced Temozolomide-Induced Anticancer Activity in Human Glioma Through the p53-PUMA Apoptosis Pathway. Front Oncol. 2021 Oct 1;11:722754. doi: 10.3389/fonc.2021.722754. eCollection 2021. (*Corresponding author).
  11. Tsou HH, Tsai HC, Chu CT, Cheng HW, Liu CJ, Lee CH, Liu TY, Wang HT*. Cigarette Smoke Containing Acrolein Upregulates EGFR Signaling Contributing to Oral Tumorigenesis In Vitro and In Vivo. Cancers (Basel). 2021 Jul 15;13(14):3544. doi: 10.3390/cancers13143544. (*Corresponding author).
  12. Tsai HC, Tsou HH, Lin CC, Chen SC, Cheng HW, Liu TY, Chen WS, Jiang JK, Yang SH, Chang SC, Teng HW, Wang HT*. Acrolein contributes to human colorectal tumorigenesis through the activation of RAS-MAPK pathway. Sci Rep. 2021 Jun 15;11(1):12590. doi: 10.1038/s41598-021-92035-z. (*Corresponding author).
  13. Huang HJ, Wang HT, Yeh TY, Lin BW, Shiao YJ, Lo YL, Lin AM. Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity. Sci Rep. 2021 Jun 14;11(1):12497. doi: 10.1038/s41598-021-91507-6.
  14. Tsai HC, Wei KC, Chen PY, Huang CY, Chen KT, Lin YJ, Cheng HW, Huang CH, Wang HT* Receptor-Interacting Protein 140 Enhanced Temozolomide-Induced Cellular Apoptosis Through Regulation of E2F1 in Human Glioma Cell Lines. Neuromolecular Med. 2021 Jun 1. doi: 10.1007/s12017-021-08667-x. (*Corresponding author).
  15. Hong JH, Lee PAH, Lu YC, Huang CY, Chen CH, Chiang CH, Chow PM, Jaw FS, Wang CC, Huang CY, Wang TW, Liu JH, Wang HT* Acrolein contributes to urothelial carcinomas in patients with chronic kidney disease. Urol Oncol. 2020 May;38(5):465-475. doi: 10.1016/j.urolonc.2020.02.017. (*Corresponding author)
  16. Ho WC, Hsu CC, Huang HJ, Wang HT*, Lin AM*. Anti-inflammatory Effect of AZD6244 on Acrolein-Induced Neuroinflammation. Mol Neurobiol. 2020 Jan;57(1):88-95. doi: 10.1007/s12035-019-01758-8. (*Co-Corresponding author)
  17. Liu JH; Wang TW; Lin YY; Ho WC; Tsai HC; Chen SP; Anya Lin MY; Liu TY; Wang HT*. Acrolein is involved in ischemic stroke-induced neurotoxicity through spermidine/ spermine-N1-acetyltransferase activation. Exp Neurol. 2020 Jan;323:113066. doi: 10.1016/j.expneurol.2019.113066. (*Corresponding author).
  18. ArecaWeng CL, Chen CC, Tsou HH, Liu TY, Wang HT*. nut procyanidins prevent ultraviolet light B-induced photoaging via suppression of cyclooxygenase-2 and matrix metalloproteinases in mouse skin. Drug Chem Toxicol. 2019 Dec 2:1-7. doi: 10.1080/01480545.2019.1696813. (*Corresponding author).
  19. Chen YT, Chen JJ, Wang HT*. Targeting RNA Polymerase I with Hernandonine Inhibits Ribosomal RNA Synthesis and Tumor Cell Growth. Mol Cancer Res. 2019 Aug 13. doi: 10.1158/1541-7786.MCR-19-0402. [Epub ahead of print] (*Corresponding author).
  20. Tsou HH, Ko HT, Chen CT, Wang TW, Lee CH, Liu TY, Wang HT* (2019, Aug). Betel quid containing safrole enhances metabolic activation of tobacco specific 4-(methylnitrosamino)-1-(3-pyridyl) -1-butanone (NNK). Environmental Pollution, 251:13-21 (2019). (*Corresponding author).
  21. Tsou HH, Hu CH, Liu JH, Liu CJ, Lee CH, Liu TY, Wang HT*. (2019, May). Acrolein Is Involved in the Synergistic Potential of Cigarette Smoking- and Betel Quid Chewing-Related Human Oral Cancer. Cancer Epidemiol Biomarkers Prev., 28(5):954-962 (2019). (*Corresponding author).
  22. Wang TW, Liu JH, Tsou HH, Liu TY, Wang HT*. (2019, Apr). Identification of acrolein metabolites in human buccal cells, blood, and urine after consumption of commercial fried food. Food Sci Nutr., 7(5):1668-1676 (2019). (*Corresponding author).
  23. Laio TY, Chen CC, Tsou HH, Liu TY, Wang HT*. (2019, Mar). Acute and Chronic Exposure of Toluene Induces Genotoxicity in Different Regions of the Brain in Normal and Allergic Mouse Models. Neurotox Res. 2019 Mar 19. doi: 10.1007/s12640-019-00024-y. [Epub ahead of print] (*Corresponding author).
  24. Chen YJ, Hsu CC, Shiao YJ, Wang HT, Lo YL, Lin AMY. (2019, Feb). Antiinflammatory effect of afatinib (an EGFR-TKI) on OGD-induced neuroinflammation. Scientific reports, 9(1):2516 (2019).

 

Invited speaker (the past three years)

  1. To Elucidate the Interplay of Aldehyde Dehydrogenase 2 and Acrolein in Chronic Kidney Diseases. 2024 Biomedical Research Symposium of National Health Research Institutes, Taiwan, 08/2024
  2. Comparison of the chemical composition of aerosols from heated tobacco products and traditional cigarette smoke and their pulmonary toxicity using a three-dimensional (3D) organotypic bronchial epithelial culture model. ASIATOX-X symposium, Taiwan, 07/2023
  3. Effect of cigarette smoking on SARS-CoV-2-induced lung injury. Mini-symposium on emerging infectious diseases, Taiwan, 02/2023
  4. The role of a toxic lipid aldehyde acrolein in diabetic nephropathy. NHRI conference on kidney failure and diabetes, Taiwan, 10/2022
  5. Household Hazard- The Role of Acrolein in Human Oral Cancer. NHRI Conference on Cancer Research, Taiwan, 09/2021
  6. Household hazard: carcinogenicity and neurotoxicity of acrolein. NHRI, Taiwan, 04/2021